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The tiger, lion, and leopard genomes publicized

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<div>Nature Communications 4, Article number: 2433 doi:10.1038/ncomms3433</div>
<div>Received 02 May 2013 Accepted 13 August 2013 Published 17 September 2013</div>
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<div><b><span style="font-size: large;">Abstract</span></b></div>
<div><span style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">Tigers and their close relatives (</span><i style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">Panthera</i><span style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">) are some of the world&rsquo;s most endangered species. &nbsp;Here we report the&nbsp;</span><i style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">de novo</i><span style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">&nbsp;assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. &nbsp;Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats&rsquo; hypercarnivorous diet and muscle strength. &nbsp;We report a snow leopard-specific genetic determinant in&nbsp;</span><i style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">EGLN1</i><span style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">&nbsp;(Met39&gt;Lys39), which is likely to be associated with adaptation to high altitude. &nbsp;We also detect a&nbsp;</span><i style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">TYR</i><span style="color: rgb(51, 51, 51); font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">260G&gt;A mutation likely responsible for the white lion coat colour. &nbsp;Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. &nbsp;Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.</span></div>
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